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1

Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors

Hanisak, Jennifer, Michael Seganish, W., McElroy, William T., Tang, Haiquin, Zhang, Rui, Tsui, Hon-Chung, Fischmann, Theirry, Tulshian, Deen, Tata, James, Sondey, Christopher, Devito, Kristine, Fosset

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 777 KB

english, 2016

2

Total Synthesis of Laulimalide: Synthesis of the Northern and Southern Fragments

Prof. Barry M. Trost, Dr. W. Michael Seganish, Dr. Cheol K. Chung, Dr. Dominique Amans

Journal:

Chemistry - A European Journal

Année:

2012

Langue:

english

Fichier:

PDF, 456 KB

english, 2012

3

Total Synthesis of Laulimalide: Assembly of the Fragments and Completion of the Synthesis of the Natural Product and a Potent Analogue

Prof. Barry M. Trost, Dr. Dominique Amans, Dr. W. Michael Seganish, Dr. Cheol K. Chung

Journal:

Chemistry - A European Journal

Année:

2012

Langue:

english

Fichier:

PDF, 481 KB

english, 2012

4

Preparation and Palladium-Catalyzed Cross-Coupling of Aryl Triethylammonium Bis(catechol) Silicates with Aryl Triflates

Seganish, W. Michael, DeShong, Philip

Journal:

Journal of Organic Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 164 KB

english, 2004

5

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

McElroy, William T., Tan, Zheng, Ho, Ginny, Paliwal, Sunil, Li, Guoqing, Seganish, W. Michael, Tulshian, Deen, Tata, James, Fischmann, Thierry O., Sondey, Christopher, Bian, Hong, Bober, Loretta, Jack

Journal:

ACS Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2015

6

Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

Seganish, W. Michael, Fischmann, Thierry O., Sherborne, Brad, Matasi, Julius, Lavey, Brian, McElroy, William T., Tulshian, Deen, Tata, James, Sondey, Christopher, Garlisi, Charles G., Devito, Kristine

Journal:

ACS Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 5.27 MB

english, 2015

7

Comprehensive Medicinal Chemistry III || Treatments for Heart Failure

Michael Seganish, W.

Année:

2017

Langue:

english

Fichier:

PDF, 2.98 MB

english, 2017

8

Design and Synthesis of Pyrrolidine-5,5-trans-lactams as Novel Mechanism Based Inhibitors of Human Cytomegalovirus Protease

W. Michael Seganish, Bruce B. Jarvis

Journal:

Année:

2003

Fichier:

PDF, 4 KB

2003

9

Preparation and Palladium-Catalyzed Cross-Coupling of Aryl Triethylammonium Bis(catechol) Silicates with Aryl Triflates.

W. Michael Seganish, Philip DeShong

Journal:

Année:

2004

Fichier:

PDF, 215 KB

2004

10

Application of Directed Orthometalation Toward the Synthesis of Aryl Siloxanes.

W. Michael Seganish, Philip DeShong

Journal:

Année:

2005

Fichier:

PDF, 30 KB

2005

11

Palladium-Catalyzed Cross-Coupling of Aryl Triethylammonium Bis(catechol) Silicates with Aryl Bromides Using Microwave Irradiation.

W. Michael Seganish, Philip DeShong

Journal:

Année:

2005

Fichier:

PDF, 29 KB

2005

12

Improved Synthesis of Aryltrialkoxysilanes via Treatment of Aryl Grignard or Lithium Reagents with Tetraalkyl Orthosilicates.

Amy S. Manoso, Chuljin Ahn, Arash Soheili, Christopher J. Handy, Reuben Correia, W. Michael Seganish, Philip DeShong

Journal:

Année:

2005

Fichier:

PDF, 33 KB

2005

13

Palladium-Catalyzed Homocoupling of Aryl Halides in the Presence of Fluoride.

W. Michael Seganish, Molly E. Mowery, Shaundra Riggleman, Philip DeShong

Journal:

Année:

2005

Fichier:

PDF, 23 KB

2005

14

Recent advances in siloxane-based aryl–aryl coupling reactions: focus on heteroaromatic systems

Christopher J. Handy, Amy S. Manoso, William T. McElroy, W. Michael Seganish, Philip DeShong

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2005

15

Facile access to enantiomerically pure bis(sulfoxide) chelates of late transition metals

Daniel R. Evans, Mingsheng Huang, W. Michael Seganish, James C. Fettinger, Tracie L. Williams

Journal:

Inorganic Chemistry Communications

Année:

2003

Langue:

english

Fichier:

PDF, 234 KB

english, 2003

16

Palladium-catalyzed homocoupling of aryl halides in the presence of fluoride

W. Michael Seganish, Molly E. Mowery, Shaundra Riggleman, Philip DeShong

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 156 KB

english, 2005

17

ChemInform Abstract: A Synthesis of Dihydroimidazo[5,1-a]isoquinolines Using a Sequential Ugi—Bischler—Napieralski Reaction Sequence.

W. Michael Seganish, Ana Bercovici, Ginny D. Ho, Hubert J. J. Loozen, Cornelis M. Timmers, Deen Tulshian

Journal:

Année:

2012

Fichier:

PDF, 35 KB

2012

18

The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia

Ginny D. Ho, W. Michael Seganish, Ana Bercovici, Deen Tulshian, William J. Greenlee, Rachel Van Rijn, Alan Hruza, Li Xiao, Diane Rindgen, Deborra Mullins, Mario Guzzi, Xiaoping Zhang, Carina Bleickard

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2012

19

A synthesis of dihydroimidazo[5,1-a]isoquinolines using a sequential Ugi–Bischler–Napieralski reaction sequence

W. Michael Seganish, Ana Bercovici, Ginny D. Ho, Hubert J.J. Loozen, Cornelis M. Timmers, Deen Tulshian

Journal:

Tetrahedron Letters

Année:

2012

Langue:

english

Fichier:

PDF, 377 KB

english, 2012

20

Application of Directed Orthometalation toward the Synthesis of Aryl Siloxanes

Seganish, W. Michael, DeShong, Philip

Journal:

Journal of Organic Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 144 KB

english, 2004

21

Improved Synthesis of Aryltrialkoxysilanes via Treatment of Aryl Grignard or Lithium Reagents with Tetraalkyl Orthosilicates

Manoso, Amy S., Ahn, Chuljin, Soheili, Arash, Handy, Christopher J., Correia, Reuben, Seganish, W. Michael, DeShong, Philip

Journal:

Journal of Organic Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 270 KB

english, 2004

22

Synthesis, Structures, and Solution Behavior of Bis(sulfoxide)-Pincer Complexes of Palladium(II)

Evans, Daniel R., Huang, Mingsheng, Seganish, W. Michael, Fettinger, James C., Williams, Tracie L.

Journal:

Organometallics

Année:

2002

Langue:

english

Fichier:

PDF, 111 KB

english, 2002

23

Evaluating Transition-Metal-Catalyzed Transformations for the Synthesis of Laulimalide

Trost, Barry M., Amans, Dominique, Seganish, W. Michael, Chung, Cheol K.

Journal:

Journal of the American Chemical Society

Année:

2009

Langue:

english

Fichier:

PDF, 278 KB

english, 2009

24

Application of Aryl Siloxane Cross-Coupling to the Synthesis of Allocolchicinoids

Seganish, W. Michael, DeShong, Philip

Journal:

Organic Letters

Année:

2006

Langue:

english

Fichier:

PDF, 230 KB

english, 2006

25

Efforts Directed toward the Synthesis of Colchicine: Application of Palladium-Catalyzed Siloxane Cross-Coupling Methodology

Seganish, W. Michael, Handy, Christopher J., DeShong, Philip

Journal:

Journal of Organic Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 183 KB

english, 2005

26

Palladium-Catalyzed Cross-Coupling of Aryl Triethylammonium Bis(catechol) Silicates with Aryl Bromides Using Microwave Irradiation

Seganish, W. Michael, DeShong, Philip

Journal:

Organic Letters

Année:

2004

Langue:

english

Fichier:

PDF, 65 KB

english, 2004

27

Secured Transactions: An Integrated Classroom Approach Using Financial Statements and Acronyms

Seganish, W. Michael

Journal:

Journal of Education for Business

Année:

2005

Langue:

english

Fichier:

PDF, 103 KB

english, 2005

28

Cyclometalated Products of [(COE) 2 RhCl] 2 and 1,3-(RSCH 2 ) 2 C 6 H 4 (R = t Bu, i Pr) Are Dimeric. Synthesis, Molecular Structures, and Solution Dynamics of [μ-ClRh(H)(RSCH 2 ) 2 C 6 H 3

Evans, Daniel R., Huang, Mingsheng, Seganish, W. Michael, Chege, Esther W., Lam, Yiu-Fai, Fettinger, James C., Williams, Tracie L.

Journal:

Inorganic Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 147 KB

english, 2002

29

Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4

McElroy, William T., Michael Seganish, W., Jason Herr, R., Harding, James, Yang, Jinhai, Yet, Larry, Komanduri, Venukrishnan, Prakash, Koraboina Chandra, Lavey, Brian, Tulshian, Deen, Greenlee, Willia

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 3.67 MB

english, 2015

30

Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4

Seganish, W. Michael, McElroy, William T., Herr, R. Jason, Brumfield, Stephanie, Greenlee, William J., Harding, James, Komanduri, Venukrishnan, Matasi, Julius, Prakash, Koraboina Chandra, Tulshian, De

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 5.06 MB

english, 2015

31

Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015)

Seganish, William Michael

Journal:

Expert Opinion on Therapeutic Patents

Année:

2016

Langue:

english

Fichier:

PDF, 849 KB

english, 2016

32

Comprehensive Medicinal Chemistry III || Treatments for Heart Failure

Michael Seganish, W.

Année:

2017

Fichier:

PDF, 2.98 MB

2017

33

Small molecule agonists of toll-like receptors 7 and 8: a patent review 2014 â 2020

Kieffer, Madeleine E., Patel, Akash M., Hollingsworth, Scott A., Seganish, W. Michael

Journal:

Expert Opinion on Therapeutic Patents

Année:

2020

Fichier:

PDF, 2.55 MB

2020